beauvericin

Names

[ Name ]:
beauvericin

[Synonym ]:
1,7,13-Trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone, 4,10,16-trimethyl-6,12,18-tris(1-methylethyl)-3,9,15-tris(phenylmethyl)-, (3S,6R,9S,12R,15S,18R)-
beauvericin
BEAUVERFICIN
Cyclo(-D-a-hydroxyisovaleryl-N-Me-Phe)3
beauverin
(3S,6R,9S,12R,15S,18R)-3,9,15-Tribenzyl-6,12,18-triisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
MFCD00056846
(3S,6R,9S,12R,15S,18R)-3,9,15-tribenzyl-6,12,18-tri(propan-2-yl)-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
beauverin bassiaua vuillemin
bovein

Biological Activity

[Description]:

Beauvericin is a Fusarium mycotoxin. Beauvericin inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 3 μM in an enzyme assay using rat liver microsomes[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Acyltransferase

[Target]

ACAT

[References]

[1]. Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo). 1992 Oct;45(10):1626-32.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
975.6±65.0 °C at 760 mmHg

[ Melting Point ]:
93-94℃

[ Molecular Formula ]:
C₄₅H₅₇N₃O₉

[ Molecular Weight ]:
783.949

[ Flash Point ]:
543.8±34.3 °C

[ Exact Mass ]:
783.409485

[ PSA ]:
139.83000

[ LogP ]:
5.49

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.530

[ Storage condition ]:
2-8°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Toxicity induced by F. poae-contaminated feed and the protective effect of Montmorillonite supplementation in broilers.

Food Chem. Toxicol. 74 , 120-30, (2014)

The T-2 and HT-2 toxins, the main metabolites of Fusarium poae, induce toxicity in broilers and accumulate in tissues. Consequently, during the breeding process of broilers, diets are frequently suppl...

Development and validation of an UHPLC-MS/MS method for the determination of mycotoxins in grass silages.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 32 , 2101-12, (2015)

An ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) multi-mycotoxin analytical method was developed to simultaneously identify and quantify 20 mycotoxins in grass si...

Determination of the Mycotoxin Content in Distiller's Dried Grain with Solubles Using a Multianalyte UHPLC-MS/MS Method.

J. Agric. Food Chem. 63 , 9441-51, (2015)

There are more than 300 potential mycotoxins that can contaminate food and feed and cause adverse effects in humans and animals. The data on the co-occurrence of mycotoxins in novel animal feed materi...