PD-1/PD-L1-IN-23

Names

[ Name ]:
PD-1/PD-L1-IN-23

Biological Activity

[Description]:

PD-1/PD-L1-IN-23 is a potent and orally active inhibitor of PD-1/PD-L1. PD-1/PD-L1-IN-23 is an ester prodrug of L7. L7 is a benzo[c][1,2,5]oxadiazole derivative and biologically evaluated as inhibitors of PD-L1. PD-1/PD-L1-IN-23 displays significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1

[Target]

PD-1/PD-L1[1]

[References]

[1]. Liu L, et al. Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity. J Med Chem. 2021;64(12):8391-8409.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₀BrCl₂N₃O₆

[ Molecular Weight ]:
703.41

Related Compounds

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