1,3-Cyclohexanediyldimethanamine
Names
[ CAS No. ]:
2579-20-6
[ Name ]:
1,3-Cyclohexanediyldimethanamine
[Synonym ]:
1,3-Di(aminomethyl)cyclohexane
L6TJ A1Z C1Z
1,3-Cyclohexanebis(methylamine)
Kodak silver halide solvent HS-103
EINECS 219-941-5
1,3-Bis(aminomethyl)cyclohexane
1,3-Cyclohexanedimethanamine
1,3-Cyclohexanediyldimethanamine
Hexahydro-m-xylylenediamine
MFCD00001522
Cyclohexane-1,3-diyldimethanamine
trans 1,3-bis-aminomethylcyclohexane
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
219.9±8.0 °C at 760 mmHg
[ Melting Point ]:
-70 °C
[ Molecular Formula ]:
C8H18N2
[ Molecular Weight ]:
142.242
[ Flash Point ]:
106.1±0.0 °C
[ Exact Mass ]:
142.147003
[ PSA ]:
52.04000
[ LogP ]:
0.47
[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.478
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GU7000000
- CHEMICAL NAME :
- Cyclohexane, 1,3-bis(aminomethyl)-
- CAS REGISTRY NUMBER :
- 2579-20-6
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C8-H18-N2
- MOLECULAR WEIGHT :
- 142.28
- WISWESSER LINE NOTATION :
- L6TJ A1Z C1Z
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 880 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes
- REFERENCE :
- HURC** Huntingdon Research Center Reports. (Box 527, Brooklandville, MD 21022) Volume(issue)/page/year: -,-,1973
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
Safety Information
[ Symbol ]:
GHS05, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302 + H312-H314-H412
[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
C
[ Risk Phrases ]:
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R34:Causes burns. R22:Harmful if swallowed.
[ Safety Phrases ]:
S26-S27-S28-S36/37/39-S45-S25
[ RIDADR ]:
UN 2735 8/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
GU7000000
[ Packaging Group ]:
I
[ Hazard Class ]:
8
[ HS Code ]:
2921300090
Synthetic Route
Customs
[ HS Code ]: 2921300090
[ Summary ]:
2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
Articles
Biochim. Biophys. Acta 1589(2) , 124-39, (2002)
Retrograde transport dependent on coat protein I (COPI) was impaired using two different approaches and the effects on the retrograde transport of protein toxins were investigated. One approach was to...
Use of aminoglycoside antibiotics and related compounds to study ADP-ribosylation factor (ARF)/coatomer function in Golgi traffic.Meth. Enzymol. 329 , 372-9, (2001)
Inhibition of secretion by 1,3-Cyclohexanebis(methylamine), a dibasic compound that interferes with coatomer function.
Mol. Biol. Cell 10(4) , 921-33, (1999)
We noted previously that certain aminoglycoside antibiotics inhibit the binding of coatomer to Golgi membranes in vitro. The inhibition is mediated in part by two primary amino groups present at the 1...