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Mal-amido-PEG9-NHS ester

Names

[ CAS No. ]:
2575631-92-2

[ Name ]:
Mal-amido-PEG9-NHS ester

Biological Activity

[Description]:

Mal-amido-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H51N3O16

[ Molecular Weight ]:
733.76

Related Compounds