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Velutin

Names

[ CAS No. ]:
25739-41-7

[ Name ]:
Velutin

[Synonym ]:
4',5-dihydroxy-3',7-dimethoxyflavone
5,4'-dihydroxy-7,3'-dimethoxyflavone
Flavoyadorigenin B
5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-chromen-4-one
chrysoeriol-7-methyl ether
5,4'-dihydroxy-7,3'-dimethoxylflavone
4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-
luteolin 7,3'-dimethyl ether
Velutin
7,3'-di-O-methylluteolin

Biological Activity

[Description]:

Velutin is an aglycone extracted from Korean Mistletoe, with inhibitory activity against melanin biosynthesis. Velutin reduces osteoclast differentiation and down-regulates HIF-1α through the NF-κB pathway[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Jung SH, et al. Velutin, an Aglycone Extracted from Korean Mistletoe, with Improved Inhibitory Activity against Melanin Biosynthesis. Molecules. 2019 Jul 12;24(14).

[2]. Brito C, et al. Cytotoxicity and potential anti-inflammatory activity of velutin on RAW 264.7 cell line differentiation: Implications in periodontal bone loss. Arch Oral Biol. 2017 Nov;83:348-356

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
567.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H14O6

[ Molecular Weight ]:
314.289

[ Flash Point ]:
213.1±23.6 °C

[ Exact Mass ]:
314.079041

[ PSA ]:
89.13000

[ LogP ]:
2.06

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.646

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Related Compounds

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