HJM-561

Names

[ Name ]:
HJM-561

Biological Activity

[Description]:

HJM-561 is a potent, selective, orally bioavailable EGFR PROTAC. HJM-561 overcomes osimertinib (HY-15772)-resistant EGFR triple mutations and has anti-tumor activity[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> PROTAC >> PROTAC

[References]

[1]. Du Y, et al. HJM-561, a Potent, Selective, and Orally Bioavailable EGFR PROTAC that Overcomes Osimertinib-Resistant EGFR Triple Mutations. Mol Cancer Ther. 2022 Jul 5;21(7):1060-1066.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₅H₅₁ClN₉O₅P

[ Molecular Weight ]:
864.37

Related Compounds

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