JAK2-IN-9

Names

[ CAS No. ]:
2568842-26-0

[ Name ]:
JAK2-IN-9

Biological Activity

[Description]:

JAK2-IN-9 (Compound A8) is a selective JAK2 inhibitor (IC50: 5 nM). JAK2-IN-9 inhibits the phosphorylation of JAK2, STAT3, and STAT5. JAK2-IN-9 has metabolic stabilities. JAK2-IN-9 induces apoptosis. JAK2-IN-9 can be used for research of myeloproliferative neoplasms (MPNs)[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Research Areas >> Infection
Research Areas >> Inflammation/Immunology

[Target]

JAK2


[References]

[1]. Tian Y, et al Discovery of N-(4-(Aminomethyl)phenyl)-5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors. ACS Med Chem Lett. 2023 Aug 1;14(8):1113-1121.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H24N6O2S

[ Molecular Weight ]:
412.51

Related Compounds

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