BTK-IN-25

Names

[ Name ]:
BTK-IN-25

Biological Activity

[Description]:

BTK-IN-25 (compound 71) is a potent inhibitor of BTK, and inhibits BTK(C481S) with an IC50 value of 0.77 nM. BTK-IN-25 inhibits BTK in DOHH2 cells with an IC50 value of 1 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

[Target]

IC50: 0.77 nM (BTK(C481S))

[References]

[1]. Tan H, et al. Substituted pyrrolo[2,3-b]pyridine and pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cell proliferative disorders. World Intellectual Property Organization, WO2020239124 A1. 2020-12-03.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₇F₂N₃O₅

[ Molecular Weight ]:
523.53

Related Compounds

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