A-123189

Names

[ Name ]:
A-123189

[Synonym ]:
A 123189
A123189

Biological Activity

[Description]:

A-123189 is a selective and potent α1D antagonist with Kis of 0.312 and 0.17 for human α1D and rat α1D, respectively. A-123189 displays selectivities between 10- to 20-fold for the α1D receptor over the human α1A and rat α1A receptors[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[References]

[1]. K P Briski, et al. Antagonism of type II, but not type I glucocorticoid receptors results in elevated basal luteinizing hormone release in male rats. Bioorganic & Medicinal Chemistry Letters, Volume 11, Issue 9, 7 May 2001, Pages 1119-1121.

Chemical & Physical Properties

[ Density]:
1.261±0.06 g/cm3(Predicted)

[ Molecular Formula ]:
C₂₆H₂₈N₄O₃S

[ Molecular Weight ]:
476.59

A-123189

Names

Biological Activity

Chemical & Physical Properties

Related Compounds