HIV-1 inhibitor-22

Names

[ CAS No. ]:
2554618-33-4

[ Name ]:
HIV-1 inhibitor-22

Biological Activity

[Description]:

HIV-1 inhibitor-22 (compound 11a) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 3.63 μM for HIV-1 RT. HIV-1 inhibitor-22 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 0.304 μM and 0.201 μM, also has low cytotoxicity (CC50 > 227 μM)[1]

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[Target]

HIV-1 (WT):0.304 μM (EC50)

HIV-1 (K103N):0.201 μM (EC50)


[References]

[1]. Han S, et al. Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. Eur J Med Chem. 2020;185:111874.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H26N6O3S

[ Molecular Weight ]:
550.63

Related Compounds

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