Dexchlorpheniramine

Names

[ Name ]:
Dexchlorpheniramine

[Synonym ]:
Phendextro
(3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
D-Chlorpheniramine
dexchlorphenamine
Isomerine
Dexclorfeniramina
Fortamine
Trenelone
Polaramin
DEXCHLORPHENIRAMINE
Destral

Biological Activity

[Description]:

Dexchlorpheniramine is an potent and blood-brain barrier (BBB) penetrant histamine 1 (H1) receptor antagonist with anticholinergic properties. Dexchlorpheniramine can be used for researching allergies[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[In Vivo]

Dexchlorpheniramine (2-10 mg/kg; IP, single dosage) and Ranitidine (10-50 mg/kg) co-administration can Simultaneous blockade of H1 and H2 receptors, and protects both the cortical plate and the white matter against the excitotoxic challenge in Swiss pups pretreated with IL-9[1].

[References]

[1]. Patkai J, et al. Deleterious effects of IL-9-activated mast cells and neuroprotection by antihistamine drugs in the developing mouse brain. Pediatr Res. 2001 Aug;50(2):222-30.

Chemical & Physical Properties

[ Density]:
1.107g/cm3

[ Boiling Point ]:
379ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₉ClN₂

[ Molecular Weight ]:
274.78800

[ Flash Point ]:
183ºC

[ Exact Mass ]:
274.12400

[ PSA ]:
16.13000

[ LogP ]:
3.81860

[ Index of Refraction ]:
1.565

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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