ZC0101

Names

[ Name ]:
ZC0101

Biological Activity

[Description]:

ZC0101 is a potent, orally active IDO1 and TrxR dual inhibitor with IC50 values of 0.084 μM and 7.98 μM, respectively. ZC0101 effectively induces apoptosis and ROS accumulation in cancer cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS

[Target]

IDO1:0.084 μM (IC50)

TrxR:7.98 μM (IC50)

[In Vivo]

ZC0101 (60 mg/kg; p.o.; once) effectively suppresses IDO1 activity in vivo[1].

[References]

[1]. Fan QZ, et al. Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor. Bioorg Chem. 2020 Dec;105:104401.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₅N₃O₂

[ Molecular Weight ]:
293.32

Related Compounds

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