ISOCEMBROL

Names

[ Name ]:
ISOCEMBROL

[Synonym ]:
1H-3a,7-Methanoazulen-5(4H)-one,hexahydro-3,6,8,8-tetramethyl-,(3R,3aR,6S,7S,8aS)
CEDRALON
isocedranone
Cedralone
3,6,8,8-Tetramethylhexahydro-1H-3a,7-methanoazulene-5(4H)-one
(3R-(3alpha,3Abeta,6alpha,7beta,8aalpha))-hexahydro-3,6,8,8-tetramethyl-1H-3A,7-methanoazulen-5(4H)-one
2-Isocedranone
Cedran-9-one
9-Cedranone
Isocembrol (4R)

Biological Activity

[Description]:

Thunbergol (Isocembrol) (Compound 17) is a potent TNF-α inhibitor with an IC50 of 7.2 μM[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

TNF-α:7.2 μM (IC50)

[References]

[1]. Li G, et al. Further polyoxygenated cembranoids from South China Sea soft coral Sarcophyton ehrenbergi. Bioorg Chem. 2020 Aug;101:103993.

Chemical & Physical Properties

[ Density]:
0.876g/cm3

[ Boiling Point ]:
392.69ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₄O

[ Molecular Weight ]:
290.48300

[ Flash Point ]:
169.813ºC

[ Exact Mass ]:
290.26100

[ PSA ]:
20.23000

[ LogP ]:
5.81260

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.472

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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