Bisdemethoxycurcumin

Names

[ Name ]:
Bisdemethoxycurcumin

[Synonym ]:
1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (E,E)-
DEMETHOXYCURCUMIN,BIS
Bis(p-hydroxycinnamoyl)methane
Bisdemethoxycurcumin
1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
p,p'-Dihydroxydicinnamoylmethane
(1E,6E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
CURCUMIN 3
bis demethoxycurcumin
(1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
Bisdemethoxycucurmin
bisdemetoxycurcumin
curcumin III
bisdesmethoxycurcumin
Didemethoxycurcumin
1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (1E,6E)-

Biological Activity

[Description]:

Bisdemethoxycucurmin (p,p'-Dihydroxydicinnamoylmethane), a curcuminoid, has antioxidant and antiinflammatory activities[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. M Kuroyanagi, et al. [Some observation on curcuminoids from Zingiberaceae plants]. Yakugaku Zasshi. 1970 Nov;90(11):1467-70.

[2]. Toshiya Masuda, et al. Antioxidative and Antiinflammatory Compounds from Tropical Gingers: Isolation, Structure Determination, and Activities of Cassumunins A, B, and C, New Complex Curcuminoids from Zingiber cassumunar. J. Agric. Food Chem. 1994, 42, 9, 1850–1856

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
551.3±45.0 °C at 760 mmHg

[ Melting Point ]:
91-93℃

[ Molecular Formula ]:
C₁₉H₁₆O₄

[ Molecular Weight ]:
308.328

[ Flash Point ]:
301.3±25.2 °C

[ Exact Mass ]:
308.104858

[ PSA ]:
74.60000

[ LogP ]:
3.39

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.680

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: ≥20mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2914501900

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Bis-demethoxy curcumin analog nanoparticles: synthesis, characterization, and anticancer activity in vitro.

J. Nanosci. Nanotechnol. 14(7) , 4865-73, (2014)

We have optimized a protocol for the preparation of bisdemethoxy curcumin analog nanoparticles (BDMCA-NP) by the solvent assisted process. The structural similarities between bulk and nano BDMCA were ...

Therapeutic potential of turmeric in Alzheimer's disease: curcumin or curcuminoids?

Phytother Res. 28(4) , 517-25, (2014)

Alzheimer's disease (AD) is the most common form of dementia. There is limited choice in modern therapeutics, and drugs available have limited success with multiple side effects in addition to high co...

Differential cellular uptake and metabolism of curcuminoids in monocytes/macrophages: regulatory effects on lipid accumulation.

Br. J. Nutr. 112(1) , 8-14, (2014)

We have previously shown that curcumin (CUR) may increase lipid accumulation in cultured human acute monocytic leukaemia cell line THP-1 monocytes/macrophages, but that tetrahydrocurcumin (THC), an in...