Apoptotic agent-1

Names

[ CAS No. ]:
2490538-26-4

[ Name ]:
Apoptotic agent-1

Biological Activity

[Description]:

Apoptotic agent-1 (Compound 8a) is an apoptotic agent with high antiproliferative activity against cancer cells and low cytotoxic effect. Apoptotic agent-1 induces over-expression of Fas receptor and Cyto C genes[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[In Vitro]

Apoptotic agent-1 (Compound 8a) shows antiproliferative activity with IC50 values of 53.3, 12.9 and > 100 µM against HepG2, MCF-7 and WI-38 cells, respectively[1].

[References]

[1]. Haffez H, et al. Synthesis, biological evaluation and molecular docking studies of novel thiopyrimidine analogue as apoptotic agent with potential anticancer activity. Bioorg Chem. 2020 Nov;104:104249.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H6ClN5O2S

[ Molecular Weight ]:
319.73

Related Compounds