FGFR-IN-3

Names

[ Name ]:
FGFR-IN-3

Biological Activity

[Description]:

FGFR-IN-3 (compound 6) is an orally active, potent and BBB-penetrated FGFR (fibroblast growth factor receptor) modulator. FGFR-IN-3 shows neuroprotective activity. FGFR-IN-3 can be used for neurodegenerative diseases research[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR

Research Areas >> Neurological Disease

[In Vivo]

FGFR-IN-3 (compound 6) is sufficiently lipophilic (logP = 2.2) to passively permeate across the blood-brain barrier, and further increase in molecular lipophilicity results in boosting MBI (mechanism-based inactivation) activity[1].

[References]

[1]. Sakai H, et al. Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential. Bioorg Med Chem. 2020 Jul 15;28(14):115562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₇F₂N₅O₂

[ Molecular Weight ]:
383.44

Related Compounds

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