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H-Arg-Gln-OH hydrochloride salt

Names

[ CAS No. ]:
2483-17-2

[ Name ]:
H-Arg-Gln-OH hydrochloride salt

[Synonym ]:
L-Arginyl-L-glutamin-acetat
Arginylglutamine
Glutamine,N2-L-arginyl-(6CI,7CI)
L-Arg-L-Gln
L-Glutamine,N2-L-arginyl
L-Glutamine,L-arginyl
Glutamine,N2-L-arginyl-,L-(8CI)
N2-L-Arginyl-L-glutamin
N2-L-arginyl-L-glutamine
L-Arginyl=>L-glutamin
L-arginyl-L-glutamine
H-ARG-GLN-OH

Biological Activity

[Description]:

Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

VEGF[1]


[In Vitro]

Arginyl-Glutamine (0.5-1.5 mM; 48 h) 会导致人类 RPE 细胞中可溶性 VEGF 在培养基中的表达呈统计学意义上的剂量依赖性下降[1]。

[In Vivo]

Arginyl-Glutamine (1-5 g/kg/day as a hydrochloride salt; i.p.; twice daily) 显著抑制小鼠氧诱导视网膜病变 (OIR) 模型中的视网膜新生血管[1]。 Animal Model: C57BL6/J mouse pups, oxygen-induced retinopathy (OIR) model[1] Dosage: 1.0, 2.5, or 5 g/kg per day Administration: Intraperitoneal injection, twice daily Result: Significantly decreased preretinal nuclei. Reduced neovascular tufts and vascular leakage in retinal vessels. Reduced preretinal neovascularization by 82% ± 7% and reduced VEGF mRNA by 64% ± 9% at 5 g/kg per day.

[References]

[1]. Neu J, et al. The dipeptide Arg-Gln inhibits retinal neovascularization in the mouse model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3151-5.  

Chemical & Physical Properties

[ Molecular Formula ]:
C11H22N6O4

[ Molecular Weight ]:
302.33

[ Exact Mass ]:
338.14700

[ PSA ]:
197.41000

[ LogP ]:
1.19630

Related Compounds