USP8-IN-3

Names

[ Name ]:
USP8-IN-3

Biological Activity

[Description]:

USP8-IN-3 (Compd U51) is a deubiquitinase USP8 inhibitor with an IC50 value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI50s of 37.03 μM and 6.01 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase

[Target]

USP8:4.0 μM (IC50)

[In Vitro]

USP8-IN-3 (6.25-100 μM; 15 min) 抑制 USP8 对二聚泛素的剪切活性[1]。 Western Blot Analysis[1] Cell Line: / Concentration: 6.25 μM, 12.5 μM, 25 μM, 50 μM, and 100 μM Incubation Time: 15 min; added Di-Ub substrate for another 1 h Result: Decreased the cleaved diubiquitin level.

[References]

[1]. Li zhiyun, et al. Preparing method and application of USP8 inhibitor: China, CN111138358 A. 2020-05-12.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₈F₃N₅O₂S

[ Molecular Weight ]:
425.43

Related Compounds

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