Aramchol

Names

[ Name ]:
Aramchol

[Synonym ]:
R20-FBAC
(3β,5β,7α,12α)-7,12-Dihydroxy-3-(icosanoylamino)cholan-24-oic acid
Aramchol
Cholan-24-oic acid, 7,12-dihydroxy-3-[(1-oxoeicosyl)amino]-, (3β,5β,7α,12α)-

Biological Activity

[Description]:

Aramchol (C20-FABAC) is a conjugate of cholic acid and arachidic acid that could inhibit stearoyl coenzyme A desaturase 1 (SCD1) activity. Aramchol has potential use in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) treatment[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Safadi R, et al. The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2014 Dec;12(12):2085-91.e1.

[2]. Iruarrizaga-Lejarreta M, et al. Role of Aramchol in steatohepatitis and fibrosis in mice. Hepatol Commun. 2017 Nov;1(9):911-927.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
806.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₄H₇₉NO₅

[ Molecular Weight ]:
702.10

[ Flash Point ]:
441.3±34.3 °C

[ Exact Mass ]:
701.595825

[ PSA ]:
110.35000

[ LogP ]:
11.85

[ Vapour Pressure ]:
0.0±6.5 mmHg at 25°C

[ Index of Refraction ]:
1.529

Related Compounds

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