Influenza A virus-IN-6

Names

[ CAS No. ]:
2464415-31-2

[ Name ]:
Influenza A virus-IN-6

Biological Activity

[Description]:

Influenza A virus-IN-6 (compound 16j) is a potent and selective influenza A virus inhibitor with an IC50 of 3.88 µM and CC50 of 36.64 µM. Influenza A virus-IN-6 shows anti-IAV activity with low cytotoxicity[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Research Areas >> Inflammation/Immunology

[Target]

IC50: 3.88 µM (influenza virus); CC50: 36.64 µM (influenza virus)[1]


[In Vitro]

Influenza A virus-IN-6 (compound 16j) shows anti-influenza virus activity with an IC50 of 0.41 µM in 293T-GLUC cells.

[References]

[1]. Zhang G, et al. Design, synthesis and in vitro anti-influenza A virus evaluation of novel quinazoline derivatives containing S-acetamide and NH-acetamide moieties at C-4. Eur J Med Chem. 2020 Nov 15;206:112706.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H23N5O

[ Molecular Weight ]:
409.48

Related Compounds