2-Chloro-p-aminobenzoic acid

Names

[ Name ]:
2-Chloro-p-aminobenzoic acid

[Synonym ]:
4-Amino-2-chlorobenzoic acid
Benzoic acid, 4-amino-2-chloro-
EINECS 219-540-5
4-amino-2-chloro-benzoic acid
4-Amino-2-chlor-benzoesaeure
o-Chloro-p-aminobenzoic acid
Benzoic acid,4-amino-2-chloro
2-Chloro-4-aminobenzoic acid
MFCD03407960
2-Chloro-p-aminobenzoic acid
USAF NB-1

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
365.3±27.0 °C at 760 mmHg

[ Melting Point ]:
211 °C (dec.)(lit.)

[ Molecular Formula ]:
C₇H₆ClNO₂

[ Molecular Weight ]:
171.581

[ Flash Point ]:
174.8±23.7 °C

[ Exact Mass ]:
171.008713

[ PSA ]:
63.32000

[ LogP ]:
1.26

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.649

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG1575000

CHEMICAL NAME :: Benzoic acid, 4-amino-2-chloro-

CAS REGISTRY NUMBER :: 2457-76-3

BEILSTEIN REFERENCE NO. :: 2803668

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H6-Cl-N-O2

MOLECULAR WEIGHT :: 171.59

WISWESSER LINE NOTATION :: ZR CG DVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 500 mg/L

REFERENCE :: JGMIAN Journal of General Microbiology. (Soc. for General Microbiology, Journal Sales, 62 London Rd., Reading, RG1 5AS, UK) V.1- 1947- Volume(issue)/page/year: 18,543,1958

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DG1575000

[ HS Code ]:
29224995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Validation of high-performance liquid chromatographic methods on two silica base-deactivated reversed phases for the determination of chloroprocaine and bupivacaine.

J. Pharm. Biomed. Anal. 14(8-10) , 1251-9, (1996)

The separation of HPLC of basic drugs on silica-based reversed phases remains a major problem because of the interaction between the residual silanol groups of the silica and the amino function of the...

Intrapartum paracervical block anesthesia with 2-chloroprocaine.

Am. J. Obstet. Gynecol. 146(1) , 16-22, (1983)

Most of the reports of fetal bradycardia and acidosis following paracervical block anesthesia have involved the use of amide-linked anesthetics, such as lidocaine and mepivacaine. The purposes of this...

Comparison of lidocaine and 2-chloroprocaine in paracervical block: clinical effects and drug concentrations in mother and child.

Anesth. Analg. 62(2) , 168-73, (1983)

2-Chloroprocaine (CP) has recently been recommended as a less toxic alternative to amide-type local anesthetics due to its rapid metabolism. A double-blind, randomized study comparing CP to lidocaine ...