2-Chloro-p-aminobenzoic acid

Names

[ Name ]:
2-Chloro-p-aminobenzoic acid

[Synonym ]:
4-Amino-2-chlorobenzoic acid
Benzoic acid, 4-amino-2-chloro-
EINECS 219-540-5
4-amino-2-chloro-benzoic acid
4-Amino-2-chlor-benzoesaeure
o-Chloro-p-aminobenzoic acid
Benzoic acid,4-amino-2-chloro
2-Chloro-4-aminobenzoic acid
MFCD03407960
2-Chloro-p-aminobenzoic acid
USAF NB-1

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
365.3±27.0 °C at 760 mmHg

[ Melting Point ]:
211 °C (dec.)(lit.)

[ Molecular Formula ]:
C₇H₆ClNO₂

[ Molecular Weight ]:
171.581

[ Flash Point ]:
174.8±23.7 °C

[ Exact Mass ]:
171.008713

[ PSA ]:
63.32000

[ LogP ]:
1.26

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.649

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG1575000

CHEMICAL NAME :: Benzoic acid, 4-amino-2-chloro-

CAS REGISTRY NUMBER :: 2457-76-3

BEILSTEIN REFERENCE NO. :: 2803668

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H6-Cl-N-O2

MOLECULAR WEIGHT :: 171.59

WISWESSER LINE NOTATION :: ZR CG DVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 500 mg/L

REFERENCE :: JGMIAN Journal of General Microbiology. (Soc. for General Microbiology, Journal Sales, 62 London Rd., Reading, RG1 5AS, UK) V.1- 1947- Volume(issue)/page/year: 18,543,1958

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DG1575000

[ HS Code ]:
29224995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Validation of high-performance liquid chromatographic methods on two silica base-deactivated reversed phases for the determination of chloroprocaine and bupivacaine.

J. Pharm. Biomed. Anal. 14(8-10) , 1251-9, (1996)

The separation of HPLC of basic drugs on silica-based reversed phases remains a major problem because of the interaction between the residual silanol groups of the silica and the amino function of the...

Intrapartum paracervical block anesthesia with 2-chloroprocaine.

Am. J. Obstet. Gynecol. 146(1) , 16-22, (1983)

Most of the reports of fetal bradycardia and acidosis following paracervical block anesthesia have involved the use of amide-linked anesthetics, such as lidocaine and mepivacaine. The purposes of this...

Comparison of lidocaine and 2-chloroprocaine in paracervical block: clinical effects and drug concentrations in mother and child.

Anesth. Analg. 62(2) , 168-73, (1983)

2-Chloroprocaine (CP) has recently been recommended as a less toxic alternative to amide-type local anesthetics due to its rapid metabolism. A double-blind, randomized study comparing CP to lidocaine ...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.