NLRP3 agonist 1

Names

[ CAS No. ]:
2454019-69-1

[ Name ]:
NLRP3 agonist 1

Biological Activity

[Description]:

NLRP3 agonist 1 (compound 23) is a potent and orally active NLRP3 agonist. NLRP3 agonist 1 can activate the enzyme Caspase-1 to cleave pro-IL-1β and pro-IL-18 proinflammatory cytokines into their mature forms[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)
Research Areas >> Inflammation/Immunology

[References]

[1]. O' Donovan DH, et, al. Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice. Bioorg Med Chem Lett. 2023 Oct 12:96:129518.  

Chemical & Physical Properties

[ Molecular Formula ]:
C15H16N6

[ Molecular Weight ]:
280.33

Related Compounds

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