spiclomazine

Names

[ Name ]:
spiclomazine

[Synonym ]:
Spiclomazine [INN]
Clospirazine
Spiclomazinum [INN-Latin]
Spiclomazinum
Espiclomazina
Spiclomazine

Biological Activity

[Description]:

Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRAS(G12C)

[References]

[1]. Guo X, et al. Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer. Oncotarget. 2018 Jan 8;9(6):6938-6951.

Chemical & Physical Properties

[ Density]:
1.42g/cm3

[ Boiling Point ]:
695.3ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₂₄ClN₃OS₂

[ Molecular Weight ]:
446.03

[ Flash Point ]:
374.3ºC

[ Exact Mass ]:
445.10500

[ PSA ]:
86.18000

[ LogP ]:
5.31960

[ Vapour Pressure ]:
3.51E-19mmHg at 25°C

[ Index of Refraction ]:
1.724

Related Compounds

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