MF266-3

Names

[ Name ]:
MF266-3

[Synonym ]:
(2E)-N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[5-chloro-2-(2-naphthylmethyl)phenyl]acrylamide
2-Propenamide, N-[(5-bromo-2-methoxyphenyl)sulfonyl]-3-[5-chloro-2-(2-naphthalenylmethyl)phenyl]-, (2E)-
L-826266

Biological Activity

[Description]:

MF266-3 is a potent, selective prostaglandin E receptor subtype 3 (EP3) antagonist with Ki of 0.8 nM; displayes a relatively good selectivity over other prostanoid receptors.

[References]

References 1. Clark P. et al. J Pharmacol Exp Ther. 2008 May;325(2):425-34. 2. Juteau H, et al. Bioorg Med Chem. 2001 Aug;9(8):1977-84. View Related Products by Target Prostaglandin Receptor

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₂₇H₂₁BrClNO₄S

[ Molecular Weight ]:
570.882

[ Exact Mass ]:
569.006287

[ LogP ]:
8.29

[ Index of Refraction ]:
1.662

Related Compounds

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