adriamycinone

Names

[ Name ]:
adriamycinone

[Synonym ]:
14-hydroxydaunomycinone
doxorubicin hydroxyaglycone
8-glycoloyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-5,12-Naphthacenedione
Epirubicin aglycone
Doxorubicinone
Epirubicin aglycon
doxorubicin aglycone
Adriamycin-aglycon
adriamycinaglycone
MFCD00871832

Biological Activity

[Description]:

Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin[1]. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. M Joerger, et al. Pharmacokinetics of low-dose doxorubicin and metabolites in patients with AIDS-related Kaposi sarcoma. Cancer Chemother Pharmacol. 2005 May;55(5):488-96.

Chemical & Physical Properties

[ Density]:
1.671g/cm3

[ Boiling Point ]:
726.6ºC at 760 mmHg

[ Melting Point ]:
223-225ºC

[ Molecular Formula ]:
C₂₁H₁₈O₉

[ Molecular Weight ]:
414.36200

[ Flash Point ]:
260.4ºC

[ Exact Mass ]:
414.09500

[ PSA ]:
161.59000

[ LogP ]:
0.15390

[ Vapour Pressure ]:
3.7E-22mmHg at 25°C

[ Index of Refraction ]:
1.737

[ Storage condition ]:
Amber Vial, -20°C Freezer

Related Compounds

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