FGFR3-IN-3

Names

[ CAS No. ]:
2428738-41-2

[ Name ]:
FGFR3-IN-3

Biological Activity

[Description]:

FGFR3-IN-3 (compound 40a) is a potent and pan-FGFR inhibitor, with IC50s of 2.1 nM, 3.1 nM, 4.3 nM and 74 nM for FGFR1, 2, 3, and 4, respectively. FGFR3-IN-3 can be used for the research of bladder cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR

[Target]

FGFR1:2.1 nM (IC50)

FGFR2:3.1 nM (IC50)

FGFR3:4.3 nM (IC50)

FGFR4:74 nM (IC50)


[References]

[1]. Kuriwaki I, et, al. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg Med Chem. 2020 May 15;28(10):115453.

Chemical & Physical Properties

[ Molecular Formula ]:
C38H49N9O6S

[ Molecular Weight ]:
759.92

Related Compounds