NLRP3-IN-20

Names

[ CAS No. ]:
2428478-22-0

[ Name ]:
NLRP3-IN-20

Biological Activity

[Description]:

NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)
Research Areas >> Inflammation/Immunology

[Target]

NLRP3[1]


[References]

[1]. Li Z, et al. Novel Sulfonylurea-Based NLRP3 Inflammasome Inhibitor for Efficient Treatment of Nonalcoholic Steatohepatitis, Endotoxic Shock, and Colitis. J Med Chem. 2023 Sep 11.. .  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H27N3O3S

[ Molecular Weight ]:
413.53

Related Compounds

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