JAK1-IN-11

Names

[ CAS No. ]:
2427608-43-1

[ Name ]:
JAK1-IN-11

Biological Activity

[Description]:

JAK1-IN-11 (compound 11) is a potent inhibitor of JAK，with IC50s of 0.02 nM (JAK1)，and 0.44 nM (JAK2)，respectively. JAK1-IN-11 has high selectivity against JAK1 over JAK2[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK

[Target]

IC50: 0.02 nM (JAK1) 和 0.44 nM (JAK2)[1]


[References]

[1]. Shen W. et al. Amide or sulfonamide substituted hydrazine derivative applied as JAK kinase inhibitor. China, CN110724142 A. 2020-01-24.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H36N6O4S

[ Molecular Weight ]:
528.67

Related Compounds

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