Beludavimab

Names

[ Name ]:
Beludavimab

Biological Activity

[Description]:

Beludavimab (BMS 4182137; VIR 7832) is a monoclonal antibody targeting the spike glycoprotein of SARS-CoV-2. Beludavimab binds to recombinant spike protein receptor-binding domain (S-RBD) with an EC50 value of 14.9 ng/mL and a Kd of 0.21 nM[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

[In Vitro]

Beludavimab (VIR 7832) 靶向含有聚糖（位于 N343 位置）的表位，该聚糖在 S 受体结合域 (RBD) 区域的 Sarbecovirus 亚属中高度保守，不与血管紧张素转换酶 2 (ACE2) 结合竞争。Beludavimab 具有 Fc“LS”突变，可通过与 Fc 受体结合延长半衰期[1]。 Beludavima 在来自表达 FcγIIIa 的低亲和力 F/F158 等位基因的供体细胞中更有效地诱导 NK 细胞介导的抗体依赖性细胞毒性 (ADCC)。 Beludavimab 在体外中和野生型和变异假型病毒以及真正的病毒[1]。

[References]

[1]. Andrea L. Cathcart, et al. The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2. bioRxiv. April 01, 2022.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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