Kobusone

Names

[ Name ]:
Kobusone

[Synonym ]:
(1R,4R,6R,10S)-4,12,12-Trimethyl-5-oxatricyclo[8.2.0.0]dodecan-9-one
5-Oxatricyclo[8.2.0.0]dodecan-9-one, 4,12,12-trimethyl-, (1R,4R,6R,10S)-

Biological Activity

[Description]:

Kobusoneis a natural compound isolated form Aquilaria sinensis. kobusone can stimulate islet β-cellreplication in vivo, and has the potential to be used in diabeticstudy[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Yang L, et al. Sesquiterpenes and monoterpene from Aquilaria sinensis. Zhongguo Zhong Yao Za Zhi. 2012;37(13):1973-1976.

[2]. Choi JW, et al. The small molecule kobusone can stimulate islet β-cell replication in vivo. J Int Med Res. 2021;49(7):3000605211032849.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
308.0±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₂₂O₂

[ Molecular Weight ]:
222.323

[ Flash Point ]:
123.8±16.7 °C

[ Exact Mass ]:
222.161987

[ PSA ]:
29.60000

[ LogP ]:
2.21

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.491