hCA I-IN-2

Names

[ CAS No. ]:
2417232-12-1

[ Name ]:
hCA I-IN-2

Biological Activity

[Description]:

hCA I-IN-2 (Compound 6d) is a selective human carbonic anhydrase I (hCA I) inhibitor with Ki values of 18.8, 375.1, 1721 and 283.9 nM against hCA I, hCA II, hCAIX and hCAXII, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

Ki: 18.8 nM (hCA I), 283.9 nM (hCAXII), 375.1 nM (hCA II), 1721 nM (hCA IX)[1]


[References]

[1]. Singh P, et al. Synthesis and carbonic anhydrase inhibition studies of sulfonamide based indole-1,2,3-triazole chalcone hybrids. Bioorg Chem. 2020 Jun;99:103839.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H20BrN5O3S

[ Molecular Weight ]:
562.44

Related Compounds

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