Alunacedase alfa

Names

[ CAS No. ]:
2416824-55-8

[ Name ]:
Alunacedase alfa

Biological Activity

[Description]:

Alunacedase alfa (HrsACE2; GSK 2586881) is a human recombinant soluble angiotensin-converting enzyme-2 (hrsACE2). Alunacedase alfa is a genetically modified soluble form of ACE2, it decreases cell entry of SARS-CoV-2 competing for membrane-bound ACE2. Alunacedase alfa has the potential for the research of SARS-CoV-2[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[In Vitro]

Alunacedase alfa 以大约 1·2 nM 的亲和力与 SARS-CoV-2 的刺突糖蛋白结合[2]。

[References]

[1]. Abd El-Aziz TM, et al. Human recombinant soluble ACE2 (hrsACE2) shows promise for treating severe COVID-19. Signal Transduct Target Ther. 2020 Nov 3;5(1):258.  

[2]. Zoufaly A, et al. Human recombinant soluble ACE2 in severe COVID-19. Lancet Respir Med. 2020 Nov;8(11):1154-1158.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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