RET V804M-IN-1

Names

[ CAS No. ]:
2414909-94-5

[ Name ]:
RET V804M-IN-1

Biological Activity

[Description]:

RET V804M-IN-1 (compound 5) is a wt-RET -selective inhibitors of RETV804M kinase, with an IC50 of 20 nM[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

IC50: 20 nM (RETV804M)[1].

[In Vitro]

RET V804M-IN-1 (compound 5) exhibits 3.7 and 110 fold selectivity compared to wt-RET and KDR, respectively[1].

[References]

[1]. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505.

Chemical & Physical Properties

[ Density]:
1.38±0.1 g/cm3(Predicted)

[ Molecular Formula ]:
C₁₉H₁₆N₆O

[ Molecular Weight ]:
344.37

Related Compounds

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