hCAIX/XII-IN-3

Names

[ Name ]:
hCAIX/XII-IN-3

Biological Activity

[Description]:

hCAIX/XII-IN-3 (compound 6q) is a potent and selective hCAIX and hCAXIIinhibitor with Ki values of >10000, >10000, 66.2, 4.4 nM for hCAI, hCAII, hCAIX and hCAXII, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

Ki: >10000 nM (hCAI); >10000 nM (hCAII); 66.2 nM (hCAIX); 4.4 nM (hCAXII)[1].

[References]

[1]. Thacker PS, et al. Design, synthesis and biological evaluation of coumarin linked 1,2,4-oxadiazoles as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 May;98:103739.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₃F₃N₂O₄

[ Molecular Weight ]:
402.32

Related Compounds

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