hCAIX/XII-IN-2

Names

[ CAS No. ]:
2414629-82-4

[ Name ]:
hCAIX/XII-IN-2

Biological Activity

[Description]:

hCAIX/XII-IN-2 (compound 6a) is a potent and selective hCAIX and hCAXIIinhibitor with Ki values of >10000, >10000, 30.0, 3.6 nM for hCAI, hCAII, hCAIX and hCAXII, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

Ki: >10000 nM (hCAI); >10000 nM (hCAII); 30.0 nM (hCAIX); 3.6 nM (hCAXII)[1].


[References]

[1]. Thacker PS, et al. Design, synthesis and biological evaluation of coumarin linked 1,2,4-oxadiazoles as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 May;98:103739.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H14N2O4

[ Molecular Weight ]:
334.33

Related Compounds