RET-IN-21

Names

[ Name ]:
RET-IN-21

[Synonym ]:
Benzamide, 4-[5-[(4-pyridinylmethyl)amino]pyrazolo[1,5-a]pyrimidin-3-yl]-
4-{5-[(4-Pyridinylmethyl)amino]pyrazolo[1,5-a]pyrimidin-3-yl}benzamide

Biological Activity

[Description]:

RET-IN-21 is an inhibitor of receptor tyrosine kinase (RET), with the IC50 of 4.4 μM, that has antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase. ACS Med. Chem. Lett. 2020, 11, 4, 497–505

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₉H₁₆N₆O

[ Molecular Weight ]:
344.370

[ Exact Mass ]:
344.138550

[ LogP ]:
-0.72

[ Index of Refraction ]:
1.729

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.