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Thalidomide-5-NH2-CH2-COOH

Names

[ CAS No. ]:
2412056-27-8

[ Name ]:
Thalidomide-5-NH2-CH2-COOH

Biological Activity

[Description]:

Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk). Thalidomide-5-NH2-CH2-COOH is a ligand of E3 ligase. Thalidomide-5-NH2-CH2-COOH has the potential for the treatment of one or more diseases (extracted from patent WO2021170109A1) [1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

trk[1]


[References]

[1]. Jing Liu, et al. Tropomyosin receptor kinase (trk) degradation compounds and methods of use. Patent WO2021170109A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H13N3O6

[ Molecular Weight ]:
331.28

Related Compounds