FM26

Names

[ Name ]:
FM26

Biological Activity

[Description]:

FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> ROR

Research Areas >> Cancer

[Target]

IC50: 264 nM (RORγt)[1]

[In Vitro]

FM26 (compound 25; 10 μM, 24h) significantly reduces IL-17a mRNA expression 27-fold in EL4 cells[1].

[References]

[1]. Meijer FA, et al.Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists.J Med Chem. 2020 Jan 9;63(1):241-259.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₁₅ClF₃N₃O₃

[ Molecular Weight ]:
461.82

Related Compounds

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