Dimethyl-F-OICR-9429-COOH

Names

[ Name ]:
Dimethyl-F-OICR-9429-COOH

Biological Activity

[Description]:

Dimethyl-F-OICR-9429-COOH a ligand for WD40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1 intermediate 19. Dimethyl-F-OICR-9429-COOH can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Ligand for Target Protein for PROTAC[1]

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Jin J, et, al. Wd40 repeat domain protein 5 (wdr5) degradation/disruption compounds and methods of use. WO2019246570A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₆F₄N₄O₄

[ Molecular Weight ]:
546.51

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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