OICR-9429-N-C2-NH2

Names

[ Name ]:
OICR-9429-N-C2-NH2

Biological Activity

[Description]:

OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Ligand for Target Protein for PROTAC[1]

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Jin J, et, al. Wd40 repeat domain protein 5 (wdr5) degradation / disruption compounds and methods of use. WO2019246570A1.

[2]. Chung CW, et, al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₃₈F₃N₇O₂

[ Molecular Weight ]:
597.67

[ Storage condition ]:
2-8°C

Related Compounds

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