Isocurcumenol

Names

[ Name ]:
Isocurcumenol

[Synonym ]:
Isocurcumenol
9-Isopropylidene-2-methyl-6-methylene-11-oxatricyclo[6.2.1.0]undecan-8-ol
isocurcomenol
6H-3a,6-Epoxyazulen-6-ol, octahydro-3-methyl-8-methylene-5-(1-methylethylidene)-
(1S,2S,5S,8R)-9-Isopropylidene-2-methyl-6-methylene-11-oxa-tricyclo[6.2.1.01,5]undecan-8-ol
(3a,3aα,6α,8aβ)-5-isopropylidene-3-methyl-8-methylene-3a,6-epoxyperhydroazulen-6-ol
Isourecumenol

Biological Activity

[Description]:

Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC50 values of 99.1µg/mL and 178.2 µg/mL in DLA and KB cells, respectively[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Signaling Pathways >> Apoptosis >> Apoptosis

[In Vitro]

Isocurcumenol (12.5-400 µg/mL, 24-48 h) dose-dependently inhibits cancer cells proliferation[1]. isocurcumenol does not exhibit any significant toxicity on normal chicken embryo fibroblast cells and lymphocytes[1].

[References]

[1]. Lakshmi S, et al. Antitumour Effects of Isocurcumenol Isolated from Curcuma zedoaria Rhizomes on Human and Murine Cancer Cells. Int J Med Chem. 2011;2011:253962.

[2]. Resmi Mustarichiei, et al. In silico study of curcumol, curcumenol, isocurcumenol, and β-sitosterol as potential inhibitors of estrogen receptor alpha of breast cancer. Basic Medical Research. 2014

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
351.0±42.0 °C at 760 mmHg

[ Melting Point ]:
142-143℃

[ Molecular Formula ]:
C₁₅H₂₂O₂

[ Molecular Weight ]:
234.334

[ Flash Point ]:
147.9±22.1 °C

[ Exact Mass ]:
234.161987

[ PSA ]:
29.46000

[ LogP ]:
3.46

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.546

Related Compounds

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