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GLPG3970

Names

[ CAS No. ]:
2403733-82-2

[ Name ]:
GLPG3970

Biological Activity

[Description]:

GLPG3970 (compound 88) is a first-in-class SIK2/SIK3 inhibitor. GLPG3970 can be used for the research of inflammation and autoimmune disease[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> Salt-inducible Kinase (SIK)

[In Vivo]

GLPG3970 (10 mg/kg；口服，每日两次，连续五天) 在皮内注射 IL-23 诱导的银屑病表皮增生小鼠模型中降低耳厚[1]。 GLPG3970 (60 mg/kg；口服， 每日两次，直到老鼠被杀) 在小鼠胶原抗体诱导关节炎模型 (CAIA) 中，有良好的临床表现[1]。 GLPG3970 (10 mg/kg；口服， 每日两次，连续七天) 在小鼠 T 细胞转移模型中，与对照组相比降低疾病活动指数[1]。

[References]

[1]. DESROY N, et al. NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES. WO/2019/238424. 2019.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H27F3N4O4

[ Molecular Weight ]:
504.50

Related Compounds