6-Bromo-2H-1,4-benzoxazin-3(4H)-one

Names

[ Name ]:
6-Bromo-2H-1,4-benzoxazin-3(4H)-one

[Synonym ]:
2H-1,4-Benzoxazin-3(4H)-one, 6-bromo-
6-BROMO-2H-1,4-BENZOXAZIN-3(4H)-ONE
6-bromo-2H-1,4-benzoxazin-3-one
6-bromo-3,4-dihydro-2H-1,4-benzoxazin-3-one
MFCD00461173
6-bromo-2,4-dihydro-1,4-benzoxazin-3-one

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
376.8±42.0 °C at 760 mmHg

[ Melting Point ]:
220-225ºC

[ Molecular Formula ]:
C₈H₆BrNO₂

[ Molecular Weight ]:
228.043

[ Flash Point ]:
181.7±27.9 °C

[ Exact Mass ]:
226.958176

[ PSA ]:
38.33000

[ LogP ]:
1.99

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.601

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2.0

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors.

Bioorg. Med. Chem. 15 , 5912, (2007)

We report the design and synthesis of a series of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as orally bioavailable small molecule inhibitors of renin. Compounds with a 2-methyl-2-aryl substitut...