HCAIX-IN-1

Names

[ Name ]:
HCAIX-IN-1

Biological Activity

[Description]:

HCAIX-IN-1 (compound 21e) is a potent and selective HCAIX inhibitor with KIs of 694.9, 126.6, 3.3, 9.8 nM for hCA I, hCA II, hCA IX, hCA XII, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

hCA I:694.9 nM (Ki)

hCA II:126.6 nM (Ki)

hCA IX:3.3 nM (Ki)

hCA XII:9.8 nM (Ki)

[References]

[1]. Said MA,et al. Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors. Eur J Med Chem. 2020 Jan 1;185:111843.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₇N₇O₄S

[ Molecular Weight ]:
403.42

Related Compounds

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