DZD1516

Names

[ Name ]:
DZD1516

Biological Activity

[Description]:

DZD1516 is a potent and selective HER2 inhibitor (IC50=0.56 nM) with good blood-brain permeability. DZD1516 exhibits antitumor activity in CNS and subcutaneous xenograft mouse models[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

HER2

[References]

[1]. Zhang J, et al. Preclinical and clinical activity of DZD1516, a full blood-brain barrier-penetrant, highly selective HER2 inhibitor. Breast Cancer Res. 2023 Jul 6;25(1):81.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₇F₂N₇O₃

[ Molecular Weight ]:
547.56

Related Compounds

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