Argininosuccinic acid

Names

[ Name ]:
Argininosuccinic acid

[Synonym ]:
(2S)-2-[[N'-[(4S)-4-amino-4-carboxybutyl]carbamimidoyl]amino]butanedioic acid
L-Arginosuccinic acid
L-Arginosuccinate
Arginosuccinate
Arginosuccinic acid
ARGININOSUCCINIC ACID
(N(omega)-L-arginino)succinic acid
L-Argininosuccinate
L-Argininosuccinic acid

Biological Activity

[Description]:

Argininosuccinic acid participates in the fourth step of the urea cycle, with being cleaved to arginine and fumaric acid by argininosuccinic acid lyase (ASL). Argininosuccinic acid reduces reduced glutathione (GSH) level, and increases the production of reactive oxygen species in cerebral cortex and striatum. Argininosuccinic acid causes lipid peroxidation and protein oxidation, and induces oxidative stress in the developing rat brain[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[In Vitro]

Argininosuccinic acid (250-1000 μM; 1 h) 显著增加丙二醛水平，减少巯基和羰基的形成 (蛋白质氧化) 在大脑皮层[1]。 Argininosuccinic acid (250-1000 μM; 1 h) 降低 30 日龄大鼠大脑皮层还原性谷胱甘肽 (GSH) 浓度[1]。 Argininosuccinic acid (500 μM; 1 h) 增加了30 日龄大鼠大脑皮层的二氯荧光黄含量[1]。

[In Vivo]

Argininosuccinic acid (2 μM, 2 μL; 头部注射; 单剂量) 能显著诱导 30 日龄大鼠的氧化应激[1]。 Animal Model: 30-day-old rats with two small holes drilled in the skull[1] Dosage: 2 μL of a 1.0 M concentration (2 μmol in 2 μL) Administration: Injection; euthanized 2 h after treatment Result: Significantly induced lipid oxidation (MDA levels) and protein oxidation (carbonyl formation), increased ROS and RNS generation (DCFH oxidation). Significantly decreased GSH concentrations.

[References]

[1]. Seminotti B, et al. Free Radical Scavengers Prevent Argininosuccinic Acid-Induced Oxidative Stress in the Brain of Developing Rats: a New Adjuvant Therapy for Argininosuccinate Lyase Deficiency? Mol Neurobiol. 2020 Feb;57(2):1233-1244.

[2]. Nagamani SCS, et al. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2023.

Chemical & Physical Properties

[ Density]:
1.6g/cm3

[ Boiling Point ]:
548.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₈N₄O₆

[ Molecular Weight ]:
290.27300

[ Flash Point ]:
285.3ºC

[ Exact Mass ]:
290.12300

[ PSA ]:
188.33000

[ Vapour Pressure ]:
1.83E-13mmHg at 25°C

[ Index of Refraction ]:
1.623

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.