Sonrotoclax

Names

[ Name ]:
Sonrotoclax

Biological Activity

[Description]:

Sonrotoclax is a potent, orally active Bcl2 inhibitor. Sonrotoclax has effective cell killing effect against a variety of lymphoma and leukemia cell lines[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Cancer

[In Vivo]

Sonrotoclax (compound 1; 5-50 mg/kg; p.o.; 每日一次, 持续 42 天; 患有急性淋巴细胞白血病 (ALL) 异种移植物的雌性 NCG 小鼠) 具有抗肿瘤活性并抑制肿瘤生长[1]。 Animal Model: Female NCG mice with acute lymphoblastic leukemia (ALL) xenografts[1] Dosage: 5, 15, 50 mg/kg Administration: oral administration; daily, for 42 days Result: Inhibited tumor growth in a dose-dependent manner.

[References]

[1]. Nan HU, et, al. Methods of cancer treatment using bcl-2 inhibitor. WO2021110102A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₉H₅₉N₇O₇S

[ Molecular Weight ]:
890.10

Related Compounds

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