(32-Carbonyl)-RMC-5552

Names

[ Name ]:
(32-Carbonyl)-RMC-5552

Biological Activity

[Description]:

(32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2)[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Research Areas >> Cancer

[References]

[1]. Jennifer PITZEN, et al. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors. WO2019212990A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉₃H₁₃₄N₁₀O₂₄

[ Molecular Weight ]:
1776.11

Related Compounds

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