TYK2 JH2-IN-1-d3

Names

[ CAS No. ]:
2376999-19-6

[ Name ]:
TYK2 JH2-IN-1-d3

Biological Activity

[Description]:

TYK2?JH2-IN-1-d3 is the a deuterated, orally active and selective TYK2 inhibitor (compound 4h), targeting to JH2 domain (IC50=0.1 nM)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK

[Target]

TYK2 JH2 domain[1]


[References]

[1]. Xiao Z, et al. Structure-activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4' and C6 variations. Bioorg Med Chem Lett. 2023 Jul 15;91:129373.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H21D3FN9O3

[ Molecular Weight ]:
508.52