Scandenolide

Names

[ Name ]:
Scandenolide

[Synonym ]:
5H-7,4-Methenofuro(3,2-c)oxireno(f)oxacycloundecin-5,9(7H)-dione,3-(acetyloxy)-1a,2,3,7a,8,10a,11,11a-octahydro-11a-methyl-8-methylene-,(1aS-(1aR*,3R*,7S*,7aS*,10aR*,11aR*))
Skandenolid
10a-methyl-3-methylidene-2,6-dioxodecahydro-4,7-(metheno)furo[3,2-c]oxireno[f]oxacycloundecin-8(6h)-yl acetate

Biological Activity

[Description]:

Scandenolide is a sesquiterpene lactone that can be found in Philippines medicinal plant Mikania cordata. Scandenolide inhibits leukotriene and platelet activating factor synthesis in leukocytes[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[References]

[1]. Ahmed M, et ,al. Analgesic sesquiterpene dilactone from Mikania cordata. Fitoterapia. 2001 Dec;72(8):919-21.

[2]. Ysrael MC, et, al. Inhibition of leukotriene and platelet activating factor synthesis in leukocytes by the sesquiterpene lactone scandenolide. Planta Med. 1990 Jun;56(3):268-70.

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Boiling Point ]:
584.4ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₁₈O₇

[ Molecular Weight ]:
334.32

[ Flash Point ]:
260.4ºC

[ Exact Mass ]:
334.10500

[ PSA ]:
91.43000

[ LogP ]:
0.81900

[ Vapour Pressure ]:
1.21E-13mmHg at 25°C

[ Index of Refraction ]:
1.57

Related Compounds

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